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Letrozole VS Clomid

In this post we would talk in details about the differences and similarities of Letrozole vs Clomid. In fact, this is not the proper way to compare these 2 compounds because Letrozole is the active substance whilst Clomid is the brand so you compare a substance with a brand.

The proper way to compare the 2 products would be: Letrozole vs Clomiphene OR Femara vs Clomid and that’s because Femara is among the oldest and most popular brand for Letrozole whilst Clomid is among the oldest and most popular brand for Clomiphene.

In the end, regardless what brand we’re talking about, we’re actually going to check the differences between their main ingredients which are: Letrozole vs Clomiphene.

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Why Letrozole Vs Clomid Are Compared? Similarities

There are some similarities between these 2 products, otherwise they wouldn’t have been compared in the first place.

  • Letrozole is an anti estrogen that is coming in form of oral pills and Clomiphene is also classified as an anti estrogen that is coming in form of oral pills.
  • In addition to that, both these products Femara vs Clomid are considered fertility medications that are used with high success rate for stimulating ovulation.

That’s the reason why in medical settings, these 2 compounds are considered fertility products and anti estrogens.

In addition to that, because they are both working on same hormone, there are some side effects that are specific to both these products and some that can be mentioned include: nausea, headache, vomiting as well as muscle pains and possibly others.

These are pretty much the main reasons why Letrozole vs Clomid are compared as these are the similarities between them. Nonetheless, they are still very different.


What is Letrozole (Femara)?

Letrozole is the active substance in Femara which is an orally active anti estrogenic medication that is mostly used for treating postmenopausal women with breast cancer – those cancers that are requiring estrogen to grow. Letrozole is inhibiting those enzymes in the adrenal glands.

That’s the reason why Letrozole is a popular anti estrogenic medication during the administration of amortizable steroids among bodybuilders and other sportsmen running anabolic steroids.

What is Clomiphene (Clomid)?

Clomid is the most popular brand name of the active substance Clomiphene and that’s also an orally active anti estrogenic medication that is mostly used for stimulating ovulation. Clomid is considered a weak anti estrogen, instead is considered helpful among women who cannot get pregnant.

It also inhibits the estrogenic activity in some parts of the body, but it also increases the estrogenic activity in others. The compound is causing production of hormones (gonadotropins) by the pituitary gland.

That’s the reason why Clomiphene is a popular anti estrogenic medication for Post Cycle Therapy after the user of steroids stopped the use of anabolic steroids and need to regulate back the hormonal balance after the cycle.

Letrozole Vs Clomid Differences

Despite the fact that they are both anti estrogens, there are actually very little in common between the 2 compounds. Except for earlier mentioned side effects, even the adverse effects for these 2 compounds are different.


That’s because Letrozole (Femara) is actually an Aromatase Inhibitor (AI) but Clomiphene (Clomid) is actually a Selective Estrogen Receptor Modulator (SERM) and despite them both being considered anti estrogens because they work on same hormone, their mechanism of action and overall how they deal with estrogen control is completely different.

Letrozole is a very powerful inhibitor of aromatization but Clomiphene is actually very weak so during the cycle Letrozole is going to do a great job to save you from estrogen related side effects such as water retention, hypertension, gynecomastia and others.

But on the other hand, Clomid is an extremely effective selective estrogen receptor modulator that would do a great job in signaling your pituitary gland into producing more gonadotropins and therefore more testosterone, whilst Femara won’t do such a good job. Therefore, Clomid is going to be a great (better than Letrozole) compound for helping users to recover back from a steroid cycle.

Due to these 2 reasons, a lot of anabolic users buy both Letrozole and Clomiphene – one for estrogenic protection and the other one for a proper PCT plan.

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  • NOTE! In case you are searching for Letrozole Vs Clomid because of a diagnosed medical issue, we recommend to talk with your doctor about it and use the compound recommended by your doctor in dosage recommended by your doctor.

If you’re searching for Letrozole Vs Clomid for bodybuilding purposes, we can help you with more information if needed as well as with the best quality products for lowest prices on the market directly on

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