Anyone running or planning to run anabolic and androgenic steroids should consider the addition of Tamoxifen Citrate, or at least any other SERM to their plans. Usually, that’s either Tamoxifen Citrate that is sold as brand Nolvadex most commonly or Clomiphene Citrate that is sold as Clomid most commonly.
As you can notice, these are 2 compounds in the same class of drugs. They are both orally active coming as tablets. And they are both having similar administration protocols (but different doses). For example, once a day or once every other day.
That’s because according to medical documents, Tamoxifen Citrate is having a half life anywhere between 5 to 7 days.
Therefore, we can consider that the half life of Tamoxifen is 6 days.
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What is Half Life?
Half life is the amount of time required for half of the amount used of a compound to get flushed out of the system. Taken into consideration that the Tamoxifen half life is 6 days plus or minus, then it takes around 12 days for the compound to get out of the system.
Usually, Tamoxifen Citrate (Nolvadex) comes in tablets of 20 mg. This means that using one tablet, you would still have 10 mg of it left in your system after 6 days.
In order to determine this, studies have analyzed the peak blood plasma of the compound of the subject following a single oral dose of 20 mg Tamoxifen. The average peak plasma concentration which is 40 ng/mL (ranged anywhere between 35 and 45 ng/mL) has occurred about 5 hours after the dosing with the compound.
- Nonetheless, the decline in the plasma concentration of Tamoxifen was found to be biphasic. It offers a terminal elimination half-life of approximately 5 to 7 days (or as we used as a reference point – 6 days).
Interesting thing to know about Tamoxifen is that in fact, the absolute possible range of Tamoxifen half-life elimination is ranged between 4 and 11 days. There are different factors that play a role in the Tamoxifen half life. Whilst for some people it can be as low as 4 days only (in very rare cases).
For other people it can be as long as 11 days (again, in very rare cases) because for most is around 6 days (plus or minus 1 day).
More About Tamoxifen Half Life
Is considered that the long half life of Tamoxifen is due to its high plasma protein binding. As well as to the enterohepatic recirculation. It was proven that when the compound is discontinued from being administered, the levels of Tamoxifen and its metabolites were present in the body circulation for no less than 6 more weeks. That’s after studies done on women who used it for many years.
Tamoxifen Citrate is eliminated from the body through feces. Only a small amount is eliminated in urine (the compound is excreted in bile).
In the end, due to Tamoxifen’s very long half life, users may use it once a day or every other day without issues.
But generally, when used for medical purposes, Nolvadex (Tamoxifen Citrate) is recommended to be administered on a daily basis. Because it requires a while until it reaches peak blood plasma levels. So it requires a while to fully kick in your system.
Important Info About Tamoxifen Citrate
Tamoxifen Citrate (Nolvadex) in bodybuilding is used either for treating or preventing apparition of gynecomastia during the use of aromatized anabolic steroid cycles but mostly for Post Cycle Therapy (PCT) protocols.
It helps boost testosterone levels of users after the natural production of Test was suppressed during the cycle. Tamoxifen can be of great help for those trying to recover back their natural hormonal system.
- Generally, when used for PCT plans – lower doses are required compared to when used for gynecomastia. For example, for PCT plans is rarely over 40 mg a day – 2 tablets. While for gyno, doses are no less than 20 mg a day – 1 tablet, or as much as 4 tablets per day – 80 mg.
For gynecomastia issues, is used daily in order to avoid “highs and lows”. This may promote the apparition of breast tissues (gynecomastia). But for PCT plans might be used every other day, although is still used on a daily basis (1-2 tablets depending on the PCT protocol).
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